Title:Cervical Cancer: Are There Potential New Targets? An Update on Preclinical and Clinical Results
Volume: 15
Issue: 12
Author(s): Federica Tomao, Chiara Di Tucci, Ludovica Imperiale, Serena Maria Boccia, Claudia Marchetti, Innocenza Palaia, Ludovico Muzii and Pierluigi Benedetti Panici
Affiliation:
关键词:
宫颈癌，分子路径，临床前研究，靶向治疗
摘要: According to international guidelines, treatment of cervical cancer (CC) consists of surgery in early stages and
of chemoradiation in locally advanced disease. Metastatic disease is usually treated with palliative chemotherapeutic
regimens, but cytostatic drugs present significant side effects and show limited activity. Thus, the discovery of new anticancer
agents, interfering with molecular targets expressed by the tumor’s microenvironment or by the tumor cell itself,
represents a possible chance for the struggle against this tumor. The aim of this review is to report all targets that have
been investigated in preclinical and clinical studies. We discuss these potential targets according to “targeted therapies”
NCI classification. The most investigated molecular targets have been epidermal growth factor receptor (EGFR) and vascular
endothelial growth factor (VEGF), both involved in CC etiopathogenesis. Studies with anti-angiogenetic agents
showed encouraging clinical efficacy and acceptable toxicity. Other interesting results have been obtained by immunotherapeutic
strategies. Since biological characteristics of CC, especially in recurrent disease, are still partially unknown,
future studies are necessary to understand mechanisms involved in CC carcinogenesis, in order to give to patients the most
tailored and efficient treatments.
