Title:The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target
Volume: 14
Issue: 7
Author(s): Haleh Vosgha, Ali Salajegheh, Robert Anthony Smith and Alfred King-Yin Lam
Affiliation:
关键词:
许多证据表明microRNA-205（MIR-205）在正常的生理中的关键调解作用以及其在许多癌症中的异常表达。事实上，miR-205已经被证实为既是抑制肿瘤也是致癌的miRNA，通过调节不同细胞通路例如细胞存活、凋亡、血管生成和转移在肿瘤发生中扮演重要角色。作为肿瘤抑制基因， miR-205可作为细胞的增殖、迁移和侵袭的抑制剂；另一方面，作为致癌基因，miR-205促进肿瘤发生和发展；在多种类型的癌症中作用于不同靶基因实现所有这些功能。同时，miR-205也展示了其作为多种癌症治疗靶标的潜力。总的来说，miR-205在不同癌症中有重要的临床和药理相关性，并作为诊断和预后的标志物以及癌症治疗的新的分子靶标。
癌，癌症，miRNA-205
摘要: Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its
aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic
miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival,
apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation,
migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All
these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a
therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in
different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy.
