Title:Epigenetics and Periodontal Disease: Hope to Tame the Untameable
Volume: 14
Issue: 6
Author(s): Vishakha Grover, Anoop Kapoor, Ranjan Malhotra and Sonia Sachdeva
Affiliation:
关键词:
慢性炎症，表观遗传学，免疫细胞，个体化治疗，微生物感染，牙周疾病。
摘要: Epigenetics means gene expression alterations which occur due to the biochemical changes of the nucleotides
modifying structure of DNA rather than the changes in the genetic code itself as in case of mutations. The epigenome,
consisting of chromatin and its modifications, acts as a link between the inherited genome and the changes imposed by the
environment. Over the past decade, there has been mounting evidence suggestive of associations between epigenetic
modifications and various human conditions such as aging, and most common human diseases viz. cancer, cardiovascular
diseases, diabetes, rheumatoid arthritis, HIV etc and the clearest evidence as the central mechanism for common multifactorial
diseases, has been identified with the factors involved in the inflammatory response. Periodontal disease, basically
an immune-inflammatory affliction, being a multifactorial complex disease, owing to its high prevalence, chronicity and
wide ranging systemic effects, essentially calls for a better comprehension of the underlying disease mechanisms, so as to
develop and decipher the novel methodologies to combat this disease. The current paper aims to visualize periodontal disease
from an epigenetic perspective, featuring the contemporary evidence supported literature and tends to explore the
possibilities to find some explanations for perio-systemic health links, individualized and improvised diagnostic tools for
earlier detection and ways to halt the disease and help regeneration and reconstruction of the lost periodontal attachment
apparatus with the biology based approaches.
