Title:Benzimidazoles: An Ideal Privileged Drug Scaffold for the Design of Multitargeted Anti-inflammatory Ligands
Volume: 14
Issue: 9
Author(s): Gaganpreet Kaur, Maninder Kaur and Om Silakari
Affiliation:
Keywords:
Anti-inflammatory drug targets, inflammation, multi-factorial, multi-target ligand, privileged scaffold.
Abstract: The recent research area endeavors to discover ultimate multi-target ligands, an increasingly feasible and
attractive alternative to existing mono-targeted drugs for treatment of complex, multi-factorial inflammation process
which underlays plethora of debilitated health conditions. In order to improvise this option, exploration of relevant
chemical core scaffold will be an utmost need. Privileged benzimidazole scaffold being historically versatile structural
motif could offer a viable starting point in the search for novel multi-target ligands against multi-factorial inflammation
process since, when appropriately substituted, it can selectively modulate diverse receptors, pathways and enzymes
associated with the pathogenesis of inflammation. Despite this remarkable capability, the multi-target capacity of the
benzimidazole scaffold remains largely unexploited. With this in focus, the present review article attempts to provide
synopsis of published research to exemplify the valuable use of benzimidazole nucleus and focus on their suitability as
starting scaffold to develop multi-targeted anti-inflammatory ligands.