摘要
在过去几年,白藜芦醇的作用已增长至与调节葡萄糖和脂质处理的多酚家族中的其他多数成员平行。与此同时,超过十个关于白藜芦醇补充剂在肥胖和糖尿病这两个代谢疾病中功效的人类研究表明:其具有令人印象深刻的功效与缺乏临床关联示范、未考虑日摄入剂量(人均0.075至1.5 g)或研究患者的数量并存。这样的对比观测根据纳入研究的患者的胰岛素抵抗程度被提出。至今,无明确的结论可表明白藜芦醇的抗糖尿病和抗肥胖好处。相反,肥糖病动物模型一致表明白藜芦醇在脂肪细胞中损害多种胰岛素作用,削弱葡萄糖运输、脂肪生成和成脂分化。因为白藜芦醇也倾向于脂肪分解和限制促炎症脂肪因子的产生,它在啮齿动物中的调节导致脂肪沉积的限制、己糖吸收至肌肉的激活、胰岛素敏感性的改善和葡萄糖处理的便利化。面对一些对具前景抗糖尿病和抗肥胖特性的令人失望的推断出现,必须注意重新审视白藜芦醇靶标,尤其是那些在多酚摄取后可作用的靶标,必须注意重新定义对低剂量的反应。在这种背景下,人类脂肪细胞被提出作为一个简便模型用于筛选新型的可再生、远胜于或增强白藜芦醇代谢作用的多酚,此外,鉴于近来报道的作用,使用联合多酚用于治疗肥糖病并发症被提出。最后, 考虑到广泛的、包括引起体内脂肪减少、肝脏疾病缓解、肌肉功能改善、心血管和肾脏保护在内的多酚作用,多学科的方法被推荐用于未来的调查。
关键词: 胰岛素抵抗,葡萄糖运输,脂肪生成,脂肪因子,能量平衡。
Current Medicinal Chemistry
Title:Novel Strategies for Preventing Diabetes and Obesity Complications with Natural Polyphenols
Volume: 22 Issue: 1
Author(s): C. Carpene, S. Gomez-Zorita, S. Deleruyelle and M.A. Carpene
Affiliation:
关键词: 胰岛素抵抗,葡萄糖运输,脂肪生成,脂肪因子,能量平衡。
摘要: During the last years, the list of resveratrol effects has grown in parallel with the number of other members of the polyphenol family described to modulate glucose or lipid handling. In the same time, more than ten human studies on the influence of resveratrol supplementation on two related metabolic diseases, obesity and diabetes, have indicated that impressive beneficial effects co-exist with lack of demonstration of clinical relevance, irrespective of the daily dose ingested (0.075 to 1.5 g per capita) or the number of studied patients. Such contrasting observations have been proposed to depend on the degree of insulin resistance of the patients incorporated in the study. To date, no definitive conclusion can be drawn on the antidiabetic or antiobesity benefits of resveratrol. On the opposite, studies on animal models of diabesity consistently indicated that resveratrol impairs diverse insulin actions in adipocytes, blunting glucose transport, lipogenesis and adipogenesis. Since resveratrol also favours lipolysis and limits the production of proinflammatory adipokines, its administration in rodents results in limitation of fat deposition, activation of hexose uptake into muscle, improvement of insulin sensitivity, and facilitation of glucose disposal. Facing to a somewhat disappointing extrapolation to man of these promising antidiabetic and antiobesity properties, attention must be paid to re-examine resveratrol targets, especially those attainable after polyphenol ingestion and to re-define the responses to low doses. In this context, human adipocytes are proposed as a convenient model for the screening of "novel" polyphenols that can reproduce, outclass, or reinforce resveratrol metabolic actions, Moreover, the use of combination of polyphenols is proposed to treat diabesity complications in view of recently reported synergisms. Lastly, multidisciplinar approaches are recommended for future investigations, considering the wide range of polyphenol actions that induce body fat reduction, liver disease mitigation, muscle function improvement, cardiovascular and renal protection.
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Cite this article as:
C. Carpene, S. Gomez-Zorita, S. Deleruyelle and Carpene M.A., Novel Strategies for Preventing Diabetes and Obesity Complications with Natural Polyphenols, Current Medicinal Chemistry 2015; 22 (1) . https://dx.doi.org/10.2174/0929867321666140815124052
DOI https://dx.doi.org/10.2174/0929867321666140815124052 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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