摘要
多酚类是来源于植物,可能对人类健康有利的众多化合物中的一种,因此其研究在人类营养研究领域变得越来越重要。鉴于人们日益接受的观点是:慢性亚急性炎症在动物和人类胰岛素抵抗和糖尿病的发展中发挥重要作用,目前的综述旨在阐述关于非黄酮类多酚在糖尿病预防和/或治疗中的抗炎作用的信息。大多研究采用不同的培养细胞和使用表现不同类型糖尿病的动物模型,如链脲霉素或链脲霉素-烟酰胺诱导的糖尿病、遗传性糖尿病或高脂喂养诱导的糖尿病。总而言之,非黄酮类多酚减少炎症介质的产生,如糖尿病动物模型中的IL-1β ,IL-8,MCP-1,COX-2 或 iNOS。这种作用在绝大多数的研究中与改善胰岛素作用相伴而生。此外,一些非黄酮类多酚也能够改善或预防一些与糖尿病相关的病变,如肾病、心脏病或视网膜病变。已报道的有关人类研究的信息至今还很少。因此,需要新的研究去证实是否临床前研究中观察到的有利作用能够应用于人类。
关键词: 动物模型,培养的细胞,糖尿病,人类干预研究,抗炎,非黄酮类,多酚。
Current Medicinal Chemistry
Title:Potential Application of Non-flavonoid Phenolics in Diabetes: Antiinflammatory Effects
Volume: 22 Issue: 1
Author(s): J. Miranda, A. Lasa, L. Aguirre, A. Fernandez-Quintela, I. Milton and M.P. Portillo
Affiliation:
关键词: 动物模型,培养的细胞,糖尿病,人类干预研究,抗炎,非黄酮类,多酚。
摘要: Polyphenols are members of a very large family of plant-derived compounds that may have beneficial effects on human health, and thus their study has become an increasingly important area of human nutrition research. Considering that it is increasingly accepted that chronic sub-acute inflammation plays an important role in the development of insulin resistance and of diabetes in animals and in humans, the aim of the present review is to compile information concerning the anti-inflammatory effects of non-flavonoid polyphenols on diabetes prevention and/or treatment. Most of these studies have been carried out with different cultured cells and using animal models displaying different types of diabetes, such as diabetes induced by streptozotocin or streptozotocin-nicotinamide, genetic diabetes or diabetes induced by high-fat feeding. In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1β, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes. This effect is accompanied in the vast majority of these studies by improved insulin action. In addition, some of the non-flavonoid polyphenols are also able to ameliorate or prevent several pathological alterations associated with the development of diabetes, such as nephropathy, cardiopathy or retinopathy. Very little information has been reported with regard to human studies to date. Thus, new studies are needed to confirm if the beneficial effects observed in preclinical studies can apply to human beings.
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J. Miranda, A. Lasa, L. Aguirre, A. Fernandez-Quintela, I. Milton and Portillo M.P., Potential Application of Non-flavonoid Phenolics in Diabetes: Antiinflammatory Effects, Current Medicinal Chemistry 2015; 22 (1) . https://dx.doi.org/10.2174/0929867321666140815123507
DOI https://dx.doi.org/10.2174/0929867321666140815123507 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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