Title:The Potential Role of Morus Alba Leaves Extract on the Brain of Mice Infected with Schistosoma Mansoni
Volume: 13
Issue: 9
Author(s): Amira A. Bauomy
Affiliation:
Keywords:
Biochemical, brain, histopathology, mice, Morus alba, Schistosoma mansoni.
Abstract: Schistosomiasis is a neglected tropical disease which is associated with neuropsychiatric and neuropathological
disorders. Herein, the main goal of the presented work is to investigate the effect of Morus alba leaves extract in mice
brain infected with Schistosoma mansoni. Since, the resistance of Schistosomes to antischistosomal drug (praziquantel)
has been examined, schistosomiasis induced brain oxidative stress as evidenced by the decrease of glutathione level, total
antioxidant capacity and the activity of catalase significantly, while a significant elevation in the levels of nitrite/nitrate
and malondialdhyde. In addition, the infection resulted in neurochemical disturbances, the main inhibitory amino acid, γ-
aminobutyric acid level was decreased. In contrast, the level of chloride ions and acetylcholine esterase activity were
significantly increased. Moreover, the histopathological section showed some impairments in the brain. The treatment
with Morus alba leaves extract ameliorated the induced disturbances in schistosome-infected mice where the levels of
non-enzymatic and enzymatic antioxidants were elevated. On the other hand, the levels of nitrite/nitrate and
malondialdhyde were significantly reduced. Likewise, treatment of mice with Morus alba leaves extract improved the
altered levels of γ- aminobutyric acid level and chloride ion. Also, it improved the recorded impairments of the
histopathological section in the brain of schistosome infected mice.
