Abstract
Insulin analogues are a major improvement in diabetes pharmacotherapy. Rapid acting insulins have certain advantages over regular insulin, but there is a need to develop even faster acting insulin preparations, which mimic physiological insulin release in a better manner. This review discusses recent developments and patents in the field of Ultra- fast acting insulins. It classifies various approaches towards creation of an Ultra-fast acting insulin profile based upon the method used to achieve a faster onset of action. These include change in formulation of insulin, addition of excipients to insulin, and utilization of novel insulin sites or delivery methods. It examines the current state of evidence, and the developments in the field of newer insulin analogues & delivery methods.
Keywords: Aspart, diabetes mellitus, fast-acting insulin aspart, insulin, insulin analogues, insulin technique, ultra-fast insulin.
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued)
Title:Ultra-Fast Acting Insulin Analogues
Volume: 8 Issue: 2
Author(s): Sanjay Kalra and Yashdeep Gupta
Affiliation:
Keywords: Aspart, diabetes mellitus, fast-acting insulin aspart, insulin, insulin analogues, insulin technique, ultra-fast insulin.
Abstract: Insulin analogues are a major improvement in diabetes pharmacotherapy. Rapid acting insulins have certain advantages over regular insulin, but there is a need to develop even faster acting insulin preparations, which mimic physiological insulin release in a better manner. This review discusses recent developments and patents in the field of Ultra- fast acting insulins. It classifies various approaches towards creation of an Ultra-fast acting insulin profile based upon the method used to achieve a faster onset of action. These include change in formulation of insulin, addition of excipients to insulin, and utilization of novel insulin sites or delivery methods. It examines the current state of evidence, and the developments in the field of newer insulin analogues & delivery methods.
Export Options
About this article
Cite this article as:
Kalra Sanjay and Gupta Yashdeep, Ultra-Fast Acting Insulin Analogues, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) 2014; 8 (2) . https://dx.doi.org/10.2174/1872214808666140714112644
DOI https://dx.doi.org/10.2174/1872214808666140714112644 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
Related Articles
-
Cardiovascular Complications in Diabetes: Lessons from Animal Models
Current Medicinal Chemistry Common and Less Common Peripheral Nerve Disorders Associated with Diabetes
Current Diabetes Reviews Fetal Encephalomalacia Secondary to Acute Maternal Blood Loss: A Case Study
New Emirates Medical Journal Hydrogels: A Journey from Diapers to Gene Delivery
Mini-Reviews in Medicinal Chemistry Balaglitazone: A Second Generation Peroxisome Proliferator-Activated Receptor (PPAR) Gamma (γ) Agonist
Mini-Reviews in Medicinal Chemistry SGLT2 Inhibitors and Kidney Diseases: A Clinical Perspective
Current Medicinal Chemistry EDITORIAL (Thematic Issue: Retinal Neurodegeneration in the Course of Diabetes: Neuroprotection as a Potential Treatment Target)
Current Neuropharmacology Basal Bolus Dosing: A Clinical Experience
Current Diabetes Reviews Identifying S100B as a Biomarker and a Therapeutic Target For Brain Injury and Multiple Diseases
Current Medicinal Chemistry Are Antipsychotics Useful in the Treatment of Anorexia Nervosa? A Review of the Literature
Current Psychopharmacology Diabetes and its Complications - Contemporary Treatment and Potential Side Effects of Drugs to Treat Diabetes
Current Drug Safety Safety of Technosphere Inhaled Insulin
Current Drug Safety Synthetic Cannabinoids: Psychopharmacology, Clinical Aspects, Psychotic Onset
CNS & Neurological Disorders - Drug Targets Decreased Plasma Level of Lipoprotein Lipase Predicted Verbal Disfluency in Chinese Type 2 Diabetes Mellitus Patients with Early Cognitive Deficits
Current Alzheimer Research Evaluation of Early Administration of Insulin Glargine in the Acute Management of Diabetic Ketoacidosis
Current Diabetes Reviews Stem Cell-Based Immunomodulation in Type 1 Diabetes: Beyond the Regenerative Approach
Current Pharmaceutical Design Surgical Esophageal Emergencies
Current Respiratory Medicine Reviews A Review of Statistical and Machine Learning Techniques for Microvascular Complications in Type 2 Diabetes
Current Diabetes Reviews An Approach to Diabetic Ketoacidosis in an Emergency Setting
Reviews on Recent Clinical Trials Diabetes Case Identification Methods Applied to Electronic Medical Record Systems: Their Use in HIV-Infected Patients
Current HIV Research