Abstract
Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an ease of administration and therefore, for the possibility of covering large population for mass immunization. Different strategies of mucosal vaccination aimed to prevent colony formation and infection by pathogens and block its development. But a major concern with these vaccines is the degradation of protein components in stomach due to physiological conditions and gastric enzymes. Therefore, surface modified nanoparticles offer a better and stable alternative for efficient delivery and better activation of required immune responses. Natural and synthetic polymers are used to prepare nanoparticulate carrier systems for the development of oral mucosal vaccines. Amongst these, biodegradable polymers based nano-particulate carriers have been explored extensively for the development of delivery systems. Present review summarizes possible approaches and mechanisms for the systemic immunization by oral vaccines and critically discusses various polymers used, different strategies of surface modification to achieve targeting of antigen loaded nanoparticulate carrier at cellular level that are essentially required for a successful mucosal vaccination approach, and future prospects of nanoparticulate system as adjutants in oral mucosal vaccination.
Keywords: Biodegradable polymers, lectins, mucosal immunization, nanocarriers, nanoparticles, oral vaccines.
Current Drug Delivery
Title:Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery
Volume: 11 Issue: 6
Author(s): Neeraj Mishra, Devendra Singh, Sandeep Sharma and Ashish Baldi
Affiliation:
Keywords: Biodegradable polymers, lectins, mucosal immunization, nanocarriers, nanoparticles, oral vaccines.
Abstract: Mucosal administration of vaccines is one of the most popular approaches to induce desired immunity against various types of antigen and microbial in central as well as peripheral blood and in most external mucosal surfaces. The oral route is a preferred choice over parenteral route for this purpose mainly due to an ease of administration and therefore, for the possibility of covering large population for mass immunization. Different strategies of mucosal vaccination aimed to prevent colony formation and infection by pathogens and block its development. But a major concern with these vaccines is the degradation of protein components in stomach due to physiological conditions and gastric enzymes. Therefore, surface modified nanoparticles offer a better and stable alternative for efficient delivery and better activation of required immune responses. Natural and synthetic polymers are used to prepare nanoparticulate carrier systems for the development of oral mucosal vaccines. Amongst these, biodegradable polymers based nano-particulate carriers have been explored extensively for the development of delivery systems. Present review summarizes possible approaches and mechanisms for the systemic immunization by oral vaccines and critically discusses various polymers used, different strategies of surface modification to achieve targeting of antigen loaded nanoparticulate carrier at cellular level that are essentially required for a successful mucosal vaccination approach, and future prospects of nanoparticulate system as adjutants in oral mucosal vaccination.
Export Options
About this article
Cite this article as:
Mishra Neeraj, Singh Devendra, Sharma Sandeep and Baldi Ashish, Surface Modified Nanoparticulate Carrier Constructs for Oral Mucosal Vaccine Delivery, Current Drug Delivery 2014; 11 (6) . https://dx.doi.org/10.2174/1567201811666140709112040
DOI https://dx.doi.org/10.2174/1567201811666140709112040 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
Call for Papers in Thematic Issues
Advancements in Robotic and AI-based Drug Discovery and Delivery for Neurological Disorders
Neurological disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and brain tumors, pose significant challenges in drug delivery due to the blood-brain barrier's intricate structure and the complexity of neuronal networks. Traditional drug delivery methods often fall short in reaching therapeutic concentrations within the central nervous system, limiting treatment efficacy and ...read more
Electrospun Fibers as Drug Delivery Systems
In recent years, electrospun fibers have attracted considerable attention as potential platforms for drug delivery due to their distinctive properties and adaptability. These fibers feature a notable surface area-to-volume ratio and can be intentionally designed with high porosity, facilitating an increased capacity for drug loading and rendering them suitable for ...read more
Nanoemulsions in cancer therapy
Solid tumors are characterized by leaky vascular structure, defective angiogenesis and high interstitial fluid load, providing opportunities for nanoparticles to preferentially exudate and be retained in tumors. This phenomenon is commonly referred to as the enhanced permeability and retention (EPR) effect, which is considered to be an important reason why ...read more
Nanotechnology Based Chemotherapy for the treatment of Head & Neck Cancer
The escalating recurrence rates observed in Head and Neck cancer, particularly within the chemo-therapeutically treated cohort (50-60%), can be attributed to the non-selective nature of current anticancer drug delivery modalities. In this context, nanotechnology-based drug delivery systems emerge as a promising avenue for achieving precise localization of therapeutic agents to ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Double-Edged Sword of Novel Anti-Cancer Treatment: Proteasome Inhibition in the Growth Plate Causes Impairment of Longitudinal Bone Growth
Current Pediatric Reviews Predicting COVID-19 Severity Integrating RNA-Seq Data Using Machine Learning Techniques
Current Bioinformatics Bioconjugation of Ionophore Antibiotics: A Way to Obtain Hybrids with Potent Biological Activity
Mini-Reviews in Organic Chemistry Synthetic Methods Applied in the Preparation of Coumarin-based Compounds
Current Organic Chemistry Interplay between LncRNA/miRNA and TGF-β Signaling in the Tumorigenesis of Gynecological Cancer
Current Pharmaceutical Design Role of Non-coding RNA in the Pathogenesis of Intestinal Ischemia- Reperfusion Injury
Current Medicinal Chemistry The Adrenergic System in Gastrointestinal Cancers
Current Cancer Therapy Reviews Microtubules in Apoptosis Induction: Are They Necessary?
Current Cancer Drug Targets Deciphering Potential Role of Hippo Signaling Pathway in Breast Cancer: A Comprehensive Review
Current Pharmaceutical Design Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy
Current Topics in Medicinal Chemistry Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications
Current Neuropharmacology The Medical Potential of Antimicrobial Peptides from Insects
Current Topics in Medicinal Chemistry Overcoming Drug Resistance by Enhancing Apoptosis of Tumor Cells
Current Cancer Drug Targets The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature
Current Medicinal Chemistry Osthole: A Medicinally Privileged Natural Compound with its Therapeutic Potential
The Natural Products Journal Immunotherapeutic Approaches in MS: Update on Pathophysiology and Emerging Agents or Strategies 2006
Endocrine, Metabolic & Immune Disorders - Drug Targets Safety of Dipeptidyl Peptidase 4 Inhibitors for Treatment of Type 2 Diabetes
Current Drug Safety The Emerging Role of EMT-related lncRNAs in Therapy Resistance and their Applications as Biomarkers
Current Medicinal Chemistry Carbonic Anhydrase Inhibitors and the Management of Cancer
Current Topics in Medicinal Chemistry Diffusion-weighted MRI at the Late Stage after Radiotherapy for Evaluating Salivary Gland Injury
Current Medical Imaging