摘要
ATP在中枢神经系统(CNS)中的有效作用在20世纪40年代已被报道;嘌呤和嘧啶受体的克隆与特征,直到90年代初才被报道。它确定了七个P2X离子通道受体亚型,其中三个以同源多聚体或杂多聚体形成阳离子通道。P2X受体亚型广泛表达于中枢神经系统,它们的分布被不同的领域报道。它们在突触传递和神经调节,以及在营养信号方面发挥作用。从神经和星形胶质细胞释放的 ATP主要参与神经元 - 神经胶质相互作用。嘌呤信号参与正常的行为,包括学习和记忆,睡眠和觉醒,运动和摄食活动和认知。P2X受体参与CNS的病理生理学,包括外伤、炎症、阿尔茨海默氏症和帕金森氏病、多发性硬化和肌萎缩性侧索硬化症、抑郁和焦虑。P2X4和P2X7受体拮抗剂是通过小神经胶质细胞对神经性疼痛发挥治疗作用,而P2X3受体拮抗剂也减轻神经性疼痛,只是通过不同的机制。
关键词: ATP ,脑干,胶质,谷氨酸,海马,存储器,神经变性疾病,神经性疼痛,神经保护,脊髓。
Current Medicinal Chemistry
Title:Physiopathological Roles of P2X Receptors in the Central Nervous System
Volume: 22 Issue: 7
Author(s): G. Burnstock
Affiliation:
关键词: ATP ,脑干,胶质,谷氨酸,海马,存储器,神经变性疾病,神经性疼痛,神经保护,脊髓。
摘要: Potent actions of ATP in the central nervous system (CNS) were reported in the late 1940’s, but cloning and characterisation of receptors for purines and pyrimidines did not take place until the early 1990’s, which identified seven P2X ion channel receptor subtypes, three of which form the cation channel as homomultimers or heteromultimers. P2X receptor subtypes are widely expressed in the CNS and their distribution is described in different regions. They function in synaptic cotransmission and neuromodulation, as well as in trophic signalling. ATP released from nerves and astroglial cells are predominantly involved in neuron-glial interactions. Purinergic signalling is involved in normal behaviour, including learning and memory, sleep and arousal, locomotor and feeding activities and cognition. P2X receptors participate in CNS pathophysiology, including injury, inflammation, Alzheimer’s and Parkinson’s diseases, multiple sclerosis and amyotrophic lateral sclerosis, depression and anxiety. P2X4 and P2X7 receptor antagonists are effective via microglia against neuropathic pain, while P2X3 receptor antagonists also reduce neuropathic pain, but via a differernt mechanism.
Export Options
About this article
Cite this article as:
G. Burnstock , Physiopathological Roles of P2X Receptors in the Central Nervous System, Current Medicinal Chemistry 2015; 22 (7) . https://dx.doi.org/10.2174/0929867321666140706130415
DOI https://dx.doi.org/10.2174/0929867321666140706130415 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Review of the Cardiovascular and Anti-Atherogenic Effects of Ghrelin
Current Pharmaceutical Design Central Effects of Ivermectin in Alleviation of Covid-19-induced Dysautonomia
Current Drug Targets Interaction Between Bone and Muscle in Older Persons with Mobility Limitations
Current Pharmaceutical Design Pharmacology and Clinical Pharmacology of Methylarginines Used as Inhibitors of Nitric Oxide Synthases
Current Pharmaceutical Design Preface [Hot Topic: Exogenous Factors Affecting Cardiovascular and Hematological Targets (Guest Editor: R. Manjunatha Kini)]
Current Drug Targets - Cardiovascular & Hematological Disorders Editorial (Thematic Issue: Biological Toxins and Medicinal Chemistry: Research and Therapeutic Tools)
Current Topics in Medicinal Chemistry Current Strategies to Achieve Further Cardiac and Renal Protection through Enhanced Renin-Angiotensin-Aldosterone System Inhibition
Reviews on Recent Clinical Trials General or Local Anesthesia for TAVI? A Systematic Review of the Literature and Meta-Analysis
Current Pharmaceutical Design CB1 Cannabinoid Antagonists: Structure-Activity Relationships and Potential Therapeutic Applications
Current Topics in Medicinal Chemistry Update in Glaucoma Medicinal Chemistry: Emerging Evidence for the Importance of Melatonin Analogues
Current Medicinal Chemistry Intravenous Amiodarone-induced Acute Liver Failure: A Case Report and Literature Review
New Emirates Medical Journal Synthesis and DPPH Radical Scavenging Activity of 5-Arylidene-N,Ndimethylbarbiturates
Medicinal Chemistry HIF Prolyl-4-hydroxylase Interacting Proteins: Consequences for Drug Targeting
Current Pharmaceutical Design Microwave Assisted Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry Therapeutic Angiogenesis in Ischemic Heart Disease: Gene or Recombinant Vascular Growth Factor Protein Therapy?
Current Gene Therapy Fourth Generation of Synthetic Cannabinoid Receptor Agonists: A Review on the Latest Insights
Current Pharmaceutical Design Nutraceuticals for Promoting Longevity
Current Nutraceuticals Neonatal Systemic Thrombosis: An Updated Overview
Current Vascular Pharmacology Bothrops Moojeni Venom Peptides Containing Bradykinin Potentiating Peptides Sequences
Protein & Peptide Letters Impact of Inhibitors of the Renin-Angiotensin-Aldosterone System on Liver Fibrosis and Portal Hypertension
Current Medicinal Chemistry