Title:Medicinal Chemistry Discoveries among 1,3,5-Triazines: Recent Advances (2000-2013) as Antimicrobial, Anti-TB, Anti-HIV and Antimalarials
Volume: 14
Issue: 9
Author(s): Rahul V. Patel, Young-Soo Keum and Se Won Park
Affiliation:
Keywords:
Anti-TB activity, anti-HIV activity, antimalarial activity, antimicrobial activity, drug discovery, s-triazine.
Abstract: The chemistry and an extensive spectrum of biological activities of s-triazines have been examined since
several decades and this heterocyclic core has received emerging consensus. This article aims to summarize recent
advances (2000-2013) made towards the discovery of antimicrobial, antituberculosis, anti-HIV and antimalarial agents
holding 1,3,5-triazine ring as a nucleus with the substitution of several types of nucleophiles. Molecular patterns
associated with particular potency have been identified targeting several Gram-positive and Gram-negative bacteria and
some fungal species, mycobacterium tuberculosis H37Rv, HIV type I and HIV type II, particularly, HIV-1I IIB and HIV-
1ROD strains as well as a variety of P. falciparum malarial strains as chloroquine-resistant K1, chloroquine-susceptible
NF54, chloroquine-sensitive 3D7, P. falciparum (D6 clone), P. falciparum (W2 clone), cycloguanil-resistant FCR-3,
chloroquine sensitive RKL2. The report will be of considerable interest to gain useful information for the furtherance of
drug discovery with extended 1,3,5-triazine designs.