Title:Improvement of Apolipoprotein B in Argentine Indigenous School Children after Vitamin D Supplementation
Volume: 13
Issue: 2
Author(s): Valeria Hirschler, Gustavo Maccallini, Milva Sanchez, Gonzalez Claudio, Claudia Molinari, on behalf of San Antonio de los Cobres Study Group Collaborators Graciela Colque, Marcelo Figueroa, Claudio Arnada and Mariana Hidalgo
Affiliation:
Keywords:
Apo B levels, indigenous children, vitamin D supplementation, cardiovascular risk, indigenous, children, apolipoprotein.
Abstract: Objective: To determine whether vitamin D supplementation improves non-traditional
cardiovascular risk factors such as Apo B levels among indigenous children.
Methods: A prospective two-year study evaluated a treated cohort of 190 children (104 males) aged
9.4+ 2.2 years. Children were divided into group A (n=104; 54.7%) and group B (n=86; 45.3%). Both
groups received vitamin D supplementation with 100,000 u/year; group B was treated in 2013 and
group A in 2014. All subjects were evaluated at the end of each treatment and anthropometric
measures, lipids and vitamin D levels between the two groups were compared.
Results: Changes in vitamin D levels were significantly higher in Group A, which was supplied in 2014, than in group B,
which was not supplied in 2014 (6.8 vs 0.96 ng/dL; respectively). Levels of LDL-C and Apo B were improved in group A
versus B: LDL-C (-5.7 vs 6.9 mg/dL respectively) and Apo B (-0.9 vs 11. mg/dL respectively). Several multiple
regression linear analyses showed that changes in vitamin D were significantly associated with lower LDL-C levels (Beta-
0.41, p<0.01; R2 0.07); and with lower Apo B levels (Beta-0.37, p<0.01; R2 0.17).
Conclusion: Vitamin D supplementation among indigenous children could improve Apo B levels.