摘要
目的:评价胚胎时期成长受损与成人心血管疾病和死亡之间的关系。 实验内容:对宫内胚胎期与在童年和成年时期出现心脏病之间的重要关联进行综述,本文首先概括了人类心脏发育时的关键步骤, 探讨与出生时心脏中心肌细胞的数量所相关的新理论。 结果:子宫内环境决定新生儿的表观分布,这也蕴含着后天发生疾病的风险。这意味着成年期心血管疾病风险和其它病理学如肥胖的治疗方案可始于胚胎时期。结论:如果这些心血管疾病以早期症状或者潜在症状形式存在,我们就可以假设这些疾病在儿童时期是可以得到预防和治疗的,并为长期的并发症治疗提出多种方案,且比在成年后再治疗更加有效。探索子宫内胎儿生长迟滞与成年人心脏疾病在胎内初期表现形式间的相关分子作用机制是未来临床研究领域最大的挑战,将为实现在子宫内对成人心脏疾病进行初级预防的梦想做出贡献。
关键词: 心肌细胞,心血管疾病,爆发心脏病,胚胎期,围产期心脏治疗方案
Current Medicinal Chemistry
Title:Perinatal Heart Programming: Long-term Consequences
Volume: 21 Issue: 27
Author(s): A. Faa, R. Ambu, G. Faa and V. Fanos
Affiliation:
关键词: 心肌细胞,心血管疾病,爆发心脏病,胚胎期,围产期心脏治疗方案
摘要: Objective: evaluate the relationship between impaired growth during intrauterine life and adult risk of cardiovascular disease and death. Materials: review of the most important contributions to the relationship between intrauterine fetal life and heart disease insurgence in childhood and adulthood, starting with a schematic representation of the principal steps in human heart development, discussion of the new theory on the relevance of the number of cardiomyocytes that every heart shows at birth. Results: intrauterine environment defines the epigenetic profile of newborns, with implications for the risk of developing diseases later in adult life. This means that the programming of cardiovascular risk and other pathologies, such as obesity, in adulthood takes place starting from intrauterine life. Conclusions: it can be hypothesized that by preventing and eventually treating cardiovascular diseases in the pediatric age, if these are already present in their early and/or in light forms, the long-term management of complications could be approached differently and more effectively than by postponing the treatment to adulthood. The future challenge in this fascinating field of clinical research is the discovery of the molecular mechanisms underlying the association between intrauterine growth restriction and fetal onset of adult cardiac disease, so as to make a dream come true by applying primary prevention of adult heart disease in the womb.
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Cite this article as:
Faa A., Ambu R., Faa G. and Fanos V., Perinatal Heart Programming: Long-term Consequences, Current Medicinal Chemistry 2014; 21 (27) . https://dx.doi.org/10.2174/0929867321666140304094649
DOI https://dx.doi.org/10.2174/0929867321666140304094649 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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