Title:Emerging Roles of microRNAs in Neural Stem Cells
Volume: 9
Issue: 3
Author(s): Sheng Wang, Juan Xu, Rui Ye, Jing Wang, Zhaozhao Chen, Renhuan Huang, Qiang Peng, Yuanzhi Xu and Xiaoxiao Cai
Affiliation:
Keywords:
Adult neural stem cell, differentiation, embryonic neural stem cell, microRNAs, proliferation, regulation
Abstract: Neural stem cells (NSCs) are a small subset of primitive precursors that generate and maintain the main phenotypes
of the nervous system. Their ability to undergo long-term proliferation and neural differentiation endows them with
great potential in regenerative medicine. Therefore, the mechanisms by which NSCs are regulated have been widely explored
to improve their therapeutic efficacy in treating neurologic disorders. Recent progress has highlighted the significance
of microRNAs (miRNAs) in the regulation of NSC behavior. Thus, to sketch out a comprehensive image of the
regulatory mechanisms of miRNAs in NSCs, we here summarize existing evidence of the regulatory roles of diversified
miRNAs in the proliferation and neural differentiation of NSCs during embryonic neurodevelopment and adult brain
maintenance.
