Title:Stereoselective Synthesis and Application of β-Amino Ketones
Volume: 18
Issue: 2
Author(s): Nghi H. Nguyen, Andrew B. Hughes and Brad E. Sleebs
Affiliation:
Keywords:
β-amino ketones, amino alcohols, conjugate additions, diastereoselectivity, enantioselectivity, Mannich addition.
Abstract: β-Amino ketones are of increasing interest owing to their utility as important synthetic precursors in the synthesis of bioactive
molecules and natural products. As a result numerous syntheses of β-amino ketones have emerged in recent years. Of particular significance
are those methods that allow access to stereopure β-amino ketones. This review highlights recent advances in stereoselective syntheses
of β-amino ketones and also illustrates the importance of β-amino ketones as useful synthons.