Title:Evaluation of the Antipsychotic Effects of 2-(dimethylamino)- and 2-(methylamino)-7H-naphtho[1,2,3-de]quinolin-7-one Derivatives in Experimental Model of Psychosis in Mice
Volume: 14
Issue: 2
Author(s): Akbar Hajizadeh Moghaddam, Eduardo Sobarzo-Sánchez, Seyed Fazel Nabavi, Maria Daglia and Seyed Mohammad Nabavi
Affiliation:
Keywords:
Anti-schizophrenia, behavior, depressive-like, psychosis, ketamine, 7H-naphtho[1, 2, 3-de]quinolin-7-one.
Abstract: Research into novel therapeutic strategies for schizophrenia with high efficacy and low side effects has been
progressed in recent years. In the present study, anti-schizophrenia activities of 2-(dimethylamino)- and 2-(methylamino)-
7H-naphtho[1,2,3-de]quinolin-7-one derivatives (D1-D10) have been evaluated in ketamine-induced experimental schizophrenia
model in mice. For this aim, experimental animals was submitted to ketamine intraperitoneal injection at 100
mg/kg/day. Then, D1-D10 were administrated intra-cerebroventricularly to mice and in next step, animals depressive-like
behaviors have been examined by despair swimming test. The obtained results demonstrate that 7H-naphtho[1,2,3-
de]quinolin-7-one derivatives, specifically D9, reduced depressive-like behaviors via the decrease of the immobility time
and the increase of the swim and climb times. Overall, these results showed that these alkaloids have anti-schizophrenia
efficacy and due to their low side effects, they can be used as a new strategy for the treatment of depressive symptoms of
schizophrenia patients.