Title:Drug Transporters and Multiple Drug Resistance in the Most Common Pediatric Solid Tumors
Volume: 17
Issue: 4
Author(s): Doriana Fruci, William C.S. Cho, Paolo Romania, Valerio Nobili, Franco Locatelli and Anna Alisi
Affiliation:
Keywords:
ABC transporters, MDR1, MRP1, Multidrug resistance, neoadjuvant chemotherapy, pediatric solid tumors.
Abstract: Solid tumors account for approximately 30% of all pediatric cancers. Although chemotherapy has
largely contributed to strongly improve patient outcome, multidrug resistance (MDR) remains one of the major
mechanisms limiting the overall survival. The enhanced efflux rate of chemotherapeutic drugs from tumor cells
through drug transporters is one of the most important mechanisms of MDR. Drug transporters play a pivotal role
in preserving the balance between sensitivity and resistance of tumor cells to anti-neoplastic drugs. Their functional
activities have been barely investigated in pediatric solid malignancies. Here, we provide evidence from the current
literatures on drug transporters and MDR in the most common types of pediatric solid tumors, including neuroblastoma,
Wilms’ tumor, rhabdomyosarcoma, retinoblastoma, medulloblastoma and hepatoblastoma.
