Title:Biotransformations of Prenylated Hop Flavonoids for Drug Discovery and Production
Volume: 14
Issue: 10
Author(s): Agnieszka Bartmanska, Tomasz Tronina, Jaroslaw Poplonski and Ewa Huszcza
Affiliation:
Keywords:
Biotransformation, hop flavonoids, isoxanthohumol, model system, 8-prenylnaringenin, xanthohumol.
Abstract: In this review we aim to present current knowledge on biotransformation of flavonoids from hop cones with respect to type of
product, catalyst and conversion. Subsequently, a comparative analysis of biological activity of prenylated hop flavonoids and their
biotransformation products has been performed in order to indicate these research efforts that have good potential for application in
pharmaceutical industry. There is increasing evidence that the products of biotransformation of hop prenylflavonoids, which have been
little studied until recently, can be used as drugs or drug ingredients and also as standards of human drug metabolites. They can also serve
as an inspiration for the design and chemical synthesis of new derivatives with higher or different biological activity. Nevertheless, much
additional work, among others on determining the mechanism of action in in vivo systems, is needed to open up the way to biomedical
application of these compounds.