Title:Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides
Volume: 13
Issue: 14
Author(s): Kamil Kuca, Daniel Jun, Kamil Musilek, Miroslav Pohanka, Jana Zdarova Karasova and Ondrej Soukup
Affiliation:
Keywords:
Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote,
organophosphate, reactivator, protection, oxime, toxicity.
Abstract: Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different
approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase
reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase
reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase
reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in
combination with butyrylcholinesterase) and also as post-exposure treatment.
