![conference banner](/images/conference-banner.jpeg)
Abstract
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.
Keywords: Quinacrine, antiprion, prion protein, drug discovery, indole, prion diseases, pyridine dicarbonitrile, thiazole.
Current Topics in Medicinal Chemistry
Title:Prion Chemical Biology: On the Road to Therapeutics?
Volume: 13 Issue: 19
Author(s): Beining Chen, Mark Thompson, Jennifer Louth and Kai Guo
Affiliation:
Keywords: Quinacrine, antiprion, prion protein, drug discovery, indole, prion diseases, pyridine dicarbonitrile, thiazole.
Abstract: Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative diseases. So far, there is no therapy available with clinical efficacy. A detailed survey on the discovery of major classes of small molecule antiprion compounds is documented in this review in the hope that it may shine some light on the future direction of drug discovery against prion and other neurodegenerative diseases.
Export Options
About this article
Cite this article as:
Chen Beining, Thompson Mark, Louth Jennifer and Guo Kai, Prion Chemical Biology: On the Road to Therapeutics?, Current Topics in Medicinal Chemistry 2013; 13 (19) . https://dx.doi.org/10.2174/15680266113136660172
DOI https://dx.doi.org/10.2174/15680266113136660172 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Adaptogens—History and Future Perspectives
Adaptogens are pharmacologically active compounds or plant extracts that are associated with the ability to enhance the body’s stability against stress. The intake of adaptogens is associated not only with a better ability to adapt to stress and maintain or normalise metabolic functions but also with better mental and physical ...read more
AlphaFold in Medicinal Chemistry: Opportunities and Challenges
AlphaFold, a groundbreaking AI tool for protein structure prediction, is revolutionizing drug discovery. Its near-atomic accuracy unlocks new avenues for designing targeted drugs and performing efficient virtual screening. However, AlphaFold's static predictions lack the dynamic nature of proteins, crucial for understanding drug action. This is especially true for multi-domain proteins, ...read more
Artificial intelligence for Natural Products Discovery and Development
Our approach involves using computational methods to predict the potential therapeutic benefits of natural products by considering factors such as drug structure, targets, and interactions. We also employ multitarget analysis to understand the role of drug targets in disease pathways. We advocate for the use of artificial intelligence in predicting ...read more
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
TWIST1 Gene: First Insights in Felis catus
Current Genomics Comparison of Changes in Liver Function Tests in Pregnant Women with Mild and Severe COVID-19
Coronaviruses Effects of Biphenyl Sulfonylamino Methyl Bisphosphonic Acids on Porphyromonas Gingivalis and Cytokine Secretion by Oral Epithelial Cells
Medicinal Chemistry Calcium Related Genes in Dogs as Potential Cardiac Biomarkers for the Detection of Chronic Mitral Valve Disease
Recent Patents on Biomarkers Impact of Sitagliptin on Non-diabetic Covid-19 Patients
Current Molecular Pharmacology Immunotherapy for Gastroesophageal Tumors: Is there still Hope for Efficacy?
Current Cancer Drug Targets Ligustrazine Derivatives. Part 6: Design, Synthesis and Evaluation of Novel Ligustrazinyl Acylguanidine Derivatives as Potential Cardiovascular Agents
Medicinal Chemistry Editorial [Hot Topic: New Approaches to the Treatment of Inflammatory Disorders (Guest Editor: Mark L. Richards)]
Current Topics in Medicinal Chemistry Repurposing Ruxolitinib in Combating COVID-19: A Mini-review
New Emirates Medical Journal Preface
Current Nutraceuticals Computational Approaches in the Discovery and Development of Therapeutic and Prophylactic Agents for Viral Diseases
Current Topics in Medicinal Chemistry Synthetic Strategies and Biological Potential of Coumarin-Chalcone Hybrids: A New Dimension to Drug Design
Current Organic Chemistry PDF Inhibitors: An Emerging Class of Antibacterial Drugs
Current Drug Targets - Infectious Disorders Electrochemical Protein-based Bioanalytical Devices for Drug Analysis
Current Topics in Medicinal Chemistry A Review on the Role of Nitric Oxide in the Pathophysiology and Management of Sars- Cov-2 Disease
Coronaviruses Selected Natural and Synthetic Agents Effective against Parkinson’s Disease with Diverse Mechanisms
Current Topics in Medicinal Chemistry New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door
Current Medicinal Chemistry GCMS Analysis of Bioactives of <i>Piper betle</i> Linn. Leaf
Current Bioactive Compounds Pathophysiology, Current Therapeutic Options, Vaccine Candidates, and Drug Targets for Human Brucellosis
Current Molecular Pharmacology Chemical Connexin Impairment in the Developing Gonad Associated with Offspring Infertility
Current Medicinal Chemistry