Title:Capillary Electrophoresis–Mass Spectrometry in Metabolomics: The Potential for Driving Drug Discovery and Development
Volume: 14
Issue: 7
Author(s): Xu Wang, Kefeng Li, Erwin Adams and Ann Van Schepdael
Affiliation:
Keywords:
Biomarkers, CE-MS, drug discovery and development, drug efficacy, drug toxicity metabolomics.
Abstract: Metabolomics represents the global profiling of metabolites in a given biological system. It has been used to facilitate pharmaceutical
discovery and development for over a decade. Advances in instrumentation have positioned capillary electrophoresis–mass spectrometry
(CE-MS) as an important platform for both targeted and non-targeted metabolomics. In this mini-review covering the last five
years, we focus on the latest development of CE-MS based metabolomics in (a) identification and validation of novel valuable therapeutic
targets, (b) evaluation of drug efficacy, and (c) monitoring of drug unanticipated adverse effects. Some of the current issues and future
directions of CE-MS metabolomics are also discussed in the end.
