Abstract
Under TFA promoted conditions, aryl and 2-pyridyl nitriles can react with DMSO, affording methylenebisamides in moderate to good yields. While the electron-donating groups give good yields, the electron-withdrawing groups provide lower yields.
Keywords: Methylenebisamide, nitrile, DMSO.
Letters in Organic Chemistry
Title:Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO
Volume: 10 Issue: 10
Author(s): Lingxia Pan, Lin Huang and Chunsong Xie
Affiliation:
Keywords: Methylenebisamide, nitrile, DMSO.
Abstract: Under TFA promoted conditions, aryl and 2-pyridyl nitriles can react with DMSO, affording methylenebisamides in moderate to good yields. While the electron-donating groups give good yields, the electron-withdrawing groups provide lower yields.
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Cite this article as:
Pan Lingxia, Huang Lin and Xie Chunsong, Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO, Letters in Organic Chemistry 2013; 10 (10) . https://dx.doi.org/10.2174/15701786113109990049
DOI https://dx.doi.org/10.2174/15701786113109990049 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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