Title:Adipose-Derived Stem Cells and Platelet-Rich Plasma: The Keys to Functional Periodontal Tissue Engineering
Volume: 8
Issue: 5
Author(s): Morikuni Tobita and Hiroshi Mizuno
Affiliation:
Keywords:
Adipose-derived stem cells, bone regeneration, periodontal tissue engineering, platelet-rich plasma, stromal vascular
fractions.
Abstract: Numerous different types of periodontal tissue regeneration therapies have been developed clinically with variable
outcomes and serious limitations. A key goal of periodontal therapy is to regenerate the destroyed periodontal tissues
including alveolar bone, cementum and periodontal ligament. The critical factors in attaining successful periodontal tissue
regeneration are the correct recruitment of cells to the site and the production of a suitable extra cellular matrix consistent
with the periodontal tissues. Adipose tissue, from which mesenchymal stem cells can be harvested easily and safely, is an
especially attractive stem cell source, because adipose-derived stem cells have a strong potential for cell differentiation
and growth factor secretion. Meanwhile, the usefulness of platelet-rich plasma in the field of dental surgery has attracted
attention. Therapeutic effects of platelet-rich plasma are believed to occur through the provision of concentrated levels of
platelet-derived growth factors. Further, recent reports suggested the effect of platelet-rich plasma on mesenchymal stem
cell proliferation, differentiation and survival rate. Therefore, the admixture of mesenchymal stem cells and platelet-rich
plasma may indicate the great potential for tissue regenerations including periodontal tissue regeneration. In this review,
the potential of adipose-derived stem cells and platelet-rich plasma is introduced. Of particular interest, the usefulness in
periodontal tissue regeneration and future perspective is discussed.
