Abstract
Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as a oxidative stress marker and it act as a secondary signaling molecule to regulates a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discussed the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.
Keywords: 4-Hydroxy 2-nonenal, Alzheimer, cancer, cataract, oxidative stress.
Current Medicinal Chemistry
Title:4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases
Volume: 21 Issue: 2
Author(s): Mohammad Shoeb, Naseem H. Ansari, Satish K. Srivastava and Kota V. Ramana
Affiliation:
Keywords: 4-Hydroxy 2-nonenal, Alzheimer, cancer, cataract, oxidative stress.
Abstract: Metastable aldehydes produced by lipid peroxidation act as 'toxic second messengers' that extend the injurious potential of free radicals. 4-hydroxy 2-nonenal (HNE), a highly toxic and most abundant stable end product of lipid peroxidation, has been implicated in the tissue damage, dysfunction, injury associated with aging and other pathological states such as cancer, Alzheimer, diabetes, cardiovascular and inflammatory complications. Further, HNE has been considered as a oxidative stress marker and it act as a secondary signaling molecule to regulates a number of cell signaling pathways. Biological activity of HNE depends on its intracellular concentration, which can differentially modulate cell death, growth and differentiation. Therefore, the mechanisms responsible for maintaining the intracellular levels of HNE are most important, not only in the defense against oxidative stress but also in the pathophysiology of a number of disease processes. In this review, we discussed the significance of HNE in mediating various disease processes and how regulation of its metabolism could be therapeutically effective.
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Cite this article as:
Shoeb Mohammad, Ansari H. Naseem, Srivastava K. Satish and Ramana V. Kota, 4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases, Current Medicinal Chemistry 2014; 21 (2) . https://dx.doi.org/10.2174/09298673113209990181
DOI https://dx.doi.org/10.2174/09298673113209990181 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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