Title:HAART has No Major Impact on Hematological and Plasma Bilirubin Changes in HIV-Infected Patients with Congenital G-6-PD Deficiency
Volume: 11
Issue: 3
Author(s): Sakorn Pornprasert, Auttapon Panya, Chalisa L. Cheepsunthorn, Sarinee Srithep and Doungnapa Kingkeow
Affiliation:
Keywords:
G-6-PD deficiency, HAART, HIV, hemoglobin, hemolytic anemia.
Abstract: Hematological effects of antiretroviral (ARV) drugs in HIV-infected patients with glucose-6-phosphate
dehydrogenase (G-6-PD) deficiency are unclear. The aim of this study was to assess effects of highly active antiretroviral
therapy (HAART) on hematological and plasma bilirubin changes in these patients. A hundred and nine HIV-infected
Thai patients were tested for G-6-PD deficiency and its variant by using fluorescent spot test and polymerase chain
reaction-restriction fragment length polymorphism (PCR-RFLP) analysis, accordingly. Changes of hematological
parameters and plasma bilirubin at baseline and 6 months of HAART were analyzed in G-6-PD deficiency patients. G-6-
PD deficiency was found in 10 (9.17%) patients and G-6-PD Canton1376G>T was the most frequent. Of these, 3 patients
had coinheritance of G-6-PD deficiency and thalassemia. Increased mean levels of lymphocyte counts, CD4+ T-cells,
mean corpuscular hemoglobin (MCH) and hemoglobin from baseline to 6 months of HAART were observed. Whereas,
mean levels of total bilirubin and direct bilirubin at baseline were not significantly different from those at 6 months of
HAART. Therefore, HAART did not cause hemolytic anemia and hyperbilirubinemia in HIV-infected patients with G-6-
PD deficiency. On the other hand, the effective use of HAART is associated with improvements in hemoglobin and MCH
levels of these patients.