![conference banner](/images/conference-banner.jpeg)
Abstract
A series of 1-carboxyphenothiazines bearing nitrogen mustard was synthesized, characterized, and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The results showed that compounds 5h, 5i and 5j found most active with percentage inhibition of 96, 91, and 92, respectively, at minimum inhibitory concentration (MIC) of <6.25 μg/mL, among the synthesized compounds. Whereas compounds 5a, 5b, 5c, 5d, 5e, 5f and 5g exhibited considerable antitubercular activity with percentage inhibition of 71, 75, 79, 54, 55, 68, and 66, respectively, at MIC of >6.25 μg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, 1H NMR, 13C NMR, mass and elemental analysis.
Keywords: Antitubercular activity, 1-carboxyphenothiazines, Minimum inhibitory concentration, Mycobacterium tuberculosis, Nitrogen mustard, Spectroscopic tools.
Letters in Drug Design & Discovery
Title:Synthesis and Characterization of 1-carboxyphenothiazine Derivatives Bearing Nitrogen Mustard as Promising Class of Antitubercular Agents
Volume: 10 Issue: 10
Author(s): V.B. Kataria, M.J. Solanki, A.R. Trivedi and V.H. Shah
Affiliation:
Keywords: Antitubercular activity, 1-carboxyphenothiazines, Minimum inhibitory concentration, Mycobacterium tuberculosis, Nitrogen mustard, Spectroscopic tools.
Abstract: A series of 1-carboxyphenothiazines bearing nitrogen mustard was synthesized, characterized, and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The results showed that compounds 5h, 5i and 5j found most active with percentage inhibition of 96, 91, and 92, respectively, at minimum inhibitory concentration (MIC) of <6.25 μg/mL, among the synthesized compounds. Whereas compounds 5a, 5b, 5c, 5d, 5e, 5f and 5g exhibited considerable antitubercular activity with percentage inhibition of 71, 75, 79, 54, 55, 68, and 66, respectively, at MIC of >6.25 μg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, 1H NMR, 13C NMR, mass and elemental analysis.
Export Options
About this article
Cite this article as:
Kataria V.B., Solanki M.J., Trivedi A.R. and Shah V.H., Synthesis and Characterization of 1-carboxyphenothiazine Derivatives Bearing Nitrogen Mustard as Promising Class of Antitubercular Agents, Letters in Drug Design & Discovery 2013; 10 (10) . https://dx.doi.org/10.2174/15701808113109990022
DOI https://dx.doi.org/10.2174/15701808113109990022 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Call for Papers in Thematic Issues
Navigating the Frontier: Probiotics' Promising Path in Combatting Viral Respiratory Infections, Spotlight on Coronaviridae.
Probiotics, well-known for their role in gut health, show promise in preventing and managing respiratory virus infections, particularly in children and at-risk populations. However, the profound influence of novel pathogenic viral RTIs such as coronaviruses has reshaped perspectives on the potential of probiotics. Despite their potential, significant gaps remain in ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hybrid Compounds as Anti-infective Agents
Current Topics in Medicinal Chemistry Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?
Current Pharmaceutical Design Multiplex PCR is a Rapid, Simple and Cheap Method for Direct Diagnosis of M. tuberculosis from Sputum Samples
Infectious Disorders - Drug Targets Editorial [Hot Topic: Fighting Malaria in the 21st Century (Executive Editor: Pedro L. Alonso) ]
Current Molecular Medicine Properties and Potency of Small Molecule Agents for Treatment of Mycobacterium Tuberculosis Infections of the Central Nervous System
Central Nervous System Agents in Medicinal Chemistry The Methylerythritol Phosphate Pathway and its Significance as a Novel Drug Target
Current Pharmaceutical Biotechnology Bioactivity of Chitosan and Its Derivatives
Current Organic Chemistry Novel Compounds and Drugs and Recent Patents in Treating Multidrug- Resistant and Extensively Drug-Resistant Tuberculosis
Recent Patents on Anti-Infective Drug Discovery Mass Spectrometry-Based Proteomics and its Application to Studies of Porphyromonas gingivalis Invasion and Pathogenicity
Infectious Disorders - Drug Targets Deubiquitinating Enzymes as Promising Drug Targets for Infectious Diseases
Current Pharmaceutical Design 3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects
Mini-Reviews in Medicinal Chemistry Recent Updates on Biological Activities of Oxadiazoles
Mini-Reviews in Medicinal Chemistry The Activity of Alkanna Species in vitro Culture and Intact Plant Extracts Against Antibiotic Resistant Bacteria
Current Pharmaceutical Design Computational Molecular Docking and <i>In-Silico</i>, ADMET Prediction Studies of Quinoline Derivatives as EPHB4 Inhibitor
Current Indian Science Tuberculosis Therapeutics: Past Achievements, Present Road-Blocks and Future Perspectives
Letters in Drug Design & Discovery Dealing with the Substance Abuse Epidemic and Infective Endocarditis:Clinical, Immunologic and Pathogenetic Aspects
Current Vascular Pharmacology Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies
Current Topics in Medicinal Chemistry Bacillus Calmette Guerin Injection Improves Hindlimb Motor Function and Alleviates Inflammation through Upregulating Foxp3 Expression in Rats with Spinal Cord Injury
Letters in Drug Design & Discovery Natural Bioactives as Potential Therapeutic Modalities Against NeuroAIDS
Current Topics in Medicinal Chemistry Network-Based Strategies Can Help Mono- and Poly-pharmacology Drug Discovery: A Systems Biology View
Current Pharmaceutical Design