Title:Lappaconitine: Influence of Halogen Substituent on the Antiarrhythmic Activity
Volume: 11
Issue: 3
Author(s): A. O. Bryzgalov, V. E. Romanov, T. G. Tolstikova and E. E. Shults
Affiliation:
Keywords:
Arrhythmia, lappaconitine, halogen-containing lappaconitine derivatives.
Abstract: The current paper presents research results related to antiarrhythmic activity of halogen-containing derivatives
of lappaconitine. Lappaconitine derivatives with iodine, chlorine or bromine substituting the anthranilate moiety at C-5`
position were shown in vivo and in vitro to exhibit a more (Br, I) or less (Cl) pronounced antiarrhythmic activity in the
models of calcium chloride- and adrenaline-induced arrhythmias as compared with the reference compound lappaconitine.
The intensity of antiarrhythmic action depending on halogen substituent was found to be expressed by the following
order: Cl < I < Br.
