Abstract
Polyethylene glycol (PEG) encapsulation of porphyrin was designed and synthesized by introducing branched PEG substituents to the porphyrin core. Fluorescence imaging of cells was conducted to investigate the cellular uptake of these PEPPs. Results suggest that the porphyrin compound with 16 triethylene glycol chains exhibits increased cellular uptake and/or efficiency for emitting fluorescence inside the cells. The singlet oxygen yield of the porphyrin compound with 16 triethylene glycol chains is determined to be 0.93. This high singlet oxygen yield may be attributed to the large number of polyethylene glycol chains that hinder aggregation and excited-state quenching. PEPPs exhibit potential as a new class of photosensitizers for photodynamic therapy because of their water solubility, good biocompatibility, and high singlet oxygen yield.
Keywords: Porphyrins, photosensitizers, singlet oxygen yields, fluorescence imaging.
Letters in Organic Chemistry
Title:PEG Encapsulation of Porphyrins for Cell Imaging and Photodynamic Therapy
Volume: 10 Issue: 5
Author(s): Jinjun Liu, Licui Zhang, Xiaojuan Du, Fengxia Cui, Chunlei Du and Baoxiang Gao
Affiliation:
Keywords: Porphyrins, photosensitizers, singlet oxygen yields, fluorescence imaging.
Abstract: Polyethylene glycol (PEG) encapsulation of porphyrin was designed and synthesized by introducing branched PEG substituents to the porphyrin core. Fluorescence imaging of cells was conducted to investigate the cellular uptake of these PEPPs. Results suggest that the porphyrin compound with 16 triethylene glycol chains exhibits increased cellular uptake and/or efficiency for emitting fluorescence inside the cells. The singlet oxygen yield of the porphyrin compound with 16 triethylene glycol chains is determined to be 0.93. This high singlet oxygen yield may be attributed to the large number of polyethylene glycol chains that hinder aggregation and excited-state quenching. PEPPs exhibit potential as a new class of photosensitizers for photodynamic therapy because of their water solubility, good biocompatibility, and high singlet oxygen yield.
Export Options
About this article
Cite this article as:
Liu Jinjun, Zhang Licui, Du Xiaojuan, Cui Fengxia, Du Chunlei and Gao Baoxiang, PEG Encapsulation of Porphyrins for Cell Imaging and Photodynamic Therapy, Letters in Organic Chemistry 2013; 10 (5) . https://dx.doi.org/10.2174/1570178611310050007
DOI https://dx.doi.org/10.2174/1570178611310050007 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Dark Side of Stem Cells: Triggering Cancer Progression by Cell Fusion
Current Molecular Medicine Boronate Can Be the Fluorogenic Switch for the Detection of Hydrogen Peroxide
Current Medicinal Chemistry Quantitative Proteomics with Isotope Dilution Analysis: Principles and Applications
Current Proteomics Microwave-assisted Synthesis of Novel Triazolyl Pyrazolyl Pyrazoline Substituted Coumarins and Their Antimicrobial Activity
Current Microwave Chemistry Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Current Pharmaceutical Design Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis
Current Medicinal Chemistry Monitoring of Environmental Metals in Human Blood: The Need for Data Validation
Current Analytical Chemistry Antibacterial Activity of Polyphenols
Current Pharmaceutical Biotechnology Peptides Targeting Estrogen Receptor Alpha-Potential Applications for Breast Cancer Treatment
Current Pharmaceutical Design Mechanisms of Action and Chemical-Biological Interactions Between Ozone and Body Compartments: A Critical Appraisal of the Different Administration Routes
Current Drug Therapy Large Scale Preparation of the Mammalian High Mobility Group Protein A2 for Biophysical Studies
Protein & Peptide Letters Food and Gastroesophageal Reflux Disease
Current Medicinal Chemistry Synthesis of New A-CD Estrogenic Compounds: D-Homo-analogs Lacking B-ring
Current Organic Chemistry A Review on Nanostructured Lipid Carriers as Promising Drug Delivery Vehicle to Target Various Cancers <i>via</i> Oral Route: A Step towards “Chemotherapy at Home”
Current Nanomedicine Gallium-68: A New Trend in PET Radiopharmacy
Current Radiopharmaceuticals Biodegradation Aspects of Carbendazim and Sulfosulfuron: Trends, Scope and Relevance
Current Medicinal Chemistry High Throughput Automated Determination of Glutathione Based on the Formation of a UV-Absorbing Thioacrylate Derivative
Combinatorial Chemistry & High Throughput Screening Hepatitis C Virus Infection and Treatment as Independent Prognostic Factors in Diffuse Large B-Cell Lymphoma Egyptian Patients
Current Cancer Drug Targets Excisional Haemorrhoidectomy: Where Are We?
Reviews on Recent Clinical Trials Recent Studies on Design and Development of Drugs Against Alzheimer’s Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents
Current Topics in Medicinal Chemistry