Abstract
A series of substituted cinnamic acid esters were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. Compound 8 was found to be the most potent inhibitor with IC50 value of 5.60µM. Preliminary structure activity relationships (SARs) were concluded. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 8 was anti-competitive inhibitor.
Keywords: Substituted cinnamic acid esters, Tyrosinase inhibitor, Synthesis, Structure activity relationships, Inhibition kinetics, Anti-competitive inhibitor.
Letters in Drug Design & Discovery
Title:Inhibitory Effects of Substituted Cinnamic Acid Esters on Mushroom Tyrosinase
Volume: 10 Issue: 6
Author(s): Zhenghua Zhang, Jinbing Liu, Fengyan Wu and Liangzhong Zhao
Affiliation:
Keywords: Substituted cinnamic acid esters, Tyrosinase inhibitor, Synthesis, Structure activity relationships, Inhibition kinetics, Anti-competitive inhibitor.
Abstract: A series of substituted cinnamic acid esters were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. Compound 8 was found to be the most potent inhibitor with IC50 value of 5.60µM. Preliminary structure activity relationships (SARs) were concluded. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 8 was anti-competitive inhibitor.
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Cite this article as:
Zhang Zhenghua, Liu Jinbing, Wu Fengyan and Zhao Liangzhong, Inhibitory Effects of Substituted Cinnamic Acid Esters on Mushroom Tyrosinase, Letters in Drug Design & Discovery 2013; 10 (6) . https://dx.doi.org/10.2174/1570180811310060009
DOI https://dx.doi.org/10.2174/1570180811310060009 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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