Abstract
In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.
Keywords: 3(2H)-Pyridazinone, Acetohydrazide, Analgesic activity, Anti-inflammatory activity, Antibacterial activity, Antifungal activity.
Letters in Drug Design & Discovery
Title:Synthesis of Some New 3(2H)-Pyridazinone Derivatives and Evaluation of their Analgesic-anti-inflammatory and Antimicrobial Activities
Volume: 10 Issue: 6
Author(s): Murat Sukuroglu, Cem Yamali, Didem Tiryaki, Fatma Kaynak Onurdag, Esra Akkol and Deniz Songul Dogruer
Affiliation:
Keywords: 3(2H)-Pyridazinone, Acetohydrazide, Analgesic activity, Anti-inflammatory activity, Antibacterial activity, Antifungal activity.
Abstract: In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.
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Cite this article as:
Sukuroglu Murat, Yamali Cem, Tiryaki Didem, Onurdag Fatma Kaynak, Akkol Esra and Dogruer Deniz Songul, Synthesis of Some New 3(2H)-Pyridazinone Derivatives and Evaluation of their Analgesic-anti-inflammatory and Antimicrobial Activities, Letters in Drug Design & Discovery 2013; 10 (6) . https://dx.doi.org/10.2174/1570180811310060006
DOI https://dx.doi.org/10.2174/1570180811310060006 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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