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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Ubiquitin Proteasome System as a Potential Target for the Treatment of Neurodegenerative Diseases

Author(s): Zheng Ying, Hongfeng Wang and Guanghui Wang

Volume 19, Issue 18, 2013

Page: [3305 - 3314] Pages: 10

DOI: 10.2174/1381612811319180013

Price: $65

Abstract

Neurodegenerative diseases are severe disorders characterized by progressive neurodegeneration in specific brain regions. The ubiquitin-proteasome system (UPS) is closely linked to neurodegenerative disease. In most cases, UPS impairment and dysregulation of the UPS components are frequently observed. Moreover, toxin-induced neurodegeneration produces neuronal cell death accompanied by decreased UPS function. These studies suggest an involvement of the UPS in these diseases. In this review, we summarize the changes to UPS components in neurodegenerative diseases and the association between the UPS and disease pathology. Dysfunction of the UPS results in the abnormal accumulation of proteins; thus, the UPS plays a critical role in disease pathogenesis. Drugs targeting specific components of the UPS may provide promising strategies for disease treatment.

Keywords: Ubiquitin-proteasome system, deubiquitination, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis.


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