![conference banner](/images/conference-banner.jpeg)
Abstract
DHA–lysophospholipids are raising considerable interest because they are recognized as being relevant to promote the biological effects of the dietary fatty acid, docosahexaenoic acid (DHA). With a view to meet the growing demand in DHA–lysophospholipids, several research works have investigated their production. DHA–lysophospholipid production can be carried out either by chemical synthesis or enzymatic synthesis using lipases or phospholipases.
While synthesizing DHA–lysophospholipids, a special attention must be paid on the stability of the products. In this frame, caution is needed to prevent DHA oxidation. The reaction conditions also need to be optimized in order to minimize the phenomenon of acyl migration which could lead to random proportions of unwanted products.
At last, analytical methods allowing identification and the quantification of different DHA–lysophospholipid isomers, have to be implemented in order to monitor the production.
Keywords: Acyl migration, docosahexaenoic acid, lipase, lysophospholipid, oxidation, phospholipase.
Current Organic Chemistry
Title:DHA–lysophospholipid Production
Volume: 17 Issue: 8
Author(s): Gaelle Pencreac’h, Francoise Ergan and Laurent Poisson
Affiliation:
Keywords: Acyl migration, docosahexaenoic acid, lipase, lysophospholipid, oxidation, phospholipase.
Abstract: DHA–lysophospholipids are raising considerable interest because they are recognized as being relevant to promote the biological effects of the dietary fatty acid, docosahexaenoic acid (DHA). With a view to meet the growing demand in DHA–lysophospholipids, several research works have investigated their production. DHA–lysophospholipid production can be carried out either by chemical synthesis or enzymatic synthesis using lipases or phospholipases.
While synthesizing DHA–lysophospholipids, a special attention must be paid on the stability of the products. In this frame, caution is needed to prevent DHA oxidation. The reaction conditions also need to be optimized in order to minimize the phenomenon of acyl migration which could lead to random proportions of unwanted products.
At last, analytical methods allowing identification and the quantification of different DHA–lysophospholipid isomers, have to be implemented in order to monitor the production.
Export Options
About this article
Cite this article as:
Pencreac’h Gaelle, Ergan Francoise and Poisson Laurent, DHA–lysophospholipid Production, Current Organic Chemistry 2013; 17 (8) . https://dx.doi.org/10.2174/1385272811317080005
DOI https://dx.doi.org/10.2174/1385272811317080005 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
Related Journals
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Evaluation of Clozapine-induced Toxicities in Psychic Patients in Mental
Health Care Hospitals in the Southern Region of the Saudi Arabia
Kingdom
Current Drug Therapy Juvenile Neuronal Ceroid-Lipofuscinosis (Batten Disease): A Brief Review and Update
Current Molecular Medicine Minocycline: Neuroprotective Mechanisms in Parkinsons Disease
Current Pharmaceutical Design Chemokines as Potential Therapeutic Targets in Atherosclerosis
Current Drug Targets Association of Alzheimer’s Disease with Genetic Variants of Apolipoprotein E, Clusterin, TNF-α, and IL-6 Among Elderly Saudis
Current Pharmaceutical Biotechnology “A Comprehensive Review of Anaemia Associated with Hypothyroidism”
New Emirates Medical Journal Non-Lipid Effects of Statins: Emerging New Indications
Current Vascular Pharmacology The Cell Cycle Molecules Behind Neurodegeneration in Alzheimers Disease: Perspectives for Drug Development
Current Medicinal Chemistry Relationship Between Cigarette Smoking and Other Coronary Risk Factors in Atherosclerosis: Risk of Cardiovascular Disease and Preventive Measures
Current Pharmaceutical Design The Contribution of Oxazolidinone Frame to The Biological Activity of Pharmaceutical Drugs and Natural Products
Mini-Reviews in Medicinal Chemistry Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases
Current Molecular Medicine Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases
CNS & Neurological Disorders - Drug Targets Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke
Current Neuropharmacology Consensus Guideline Based Therapeutic Drug Monitoring (TDM) in Psychiatry and Neurology
Current Drug Delivery Nuclear Imaging of Inflammation in Neurologic and Psychiatric Disorders
Current Clinical Pharmacology Sex, Age, and Regional Differences in <i>CHRM1</i> and <i>CHRM3</i> Genes Expression Levels in the Human Brain Biopsies: Potential Targets for Alzheimer's Disease-related Sleep Disturbances
Current Neuropharmacology Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review
Current Neuropharmacology The Endocannabinoid System: A Promising Target for the Management of Type 2 Diabetes
Current Protein & Peptide Science Strategies for Treatment of Disease-Associated Dementia Beyond Alzheimer's Disease: An Update
Current Neuropharmacology The Renin-Angiotensin System: New Insight into Old Therapies
Current Medicinal Chemistry