Title:Radiolabeled Iron Oxide Nanoparticles As Dual-Modality SPECT/MRI and PET/MRI Agents
Volume: 12
Issue: 23
Author(s): Penelope Bouziotis, Dimitrios Psimadas, Theodoros Tsotakos, Dimosthenis Stamopoulos and Charalampos Tsoukalas
Affiliation:
Keywords:
Magnetic nanoparticles, iron oxide, radiolabeling, dual modality imaging, SPECT/MRI, PET/MRI
Abstract: Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of
diagnostic applications, since they combine the advantages of two different imaging modalities, namely SPECT or PET
imaging with MR imaging. The benefit of such a combination is to more accurately interpret disease and abnormalities in
vivo, by exploiting the advantages of each imaging technique, i.e. high sensitivity for SPECT/PET, high resolution
anatomical information for MRI. In this review article, we provide an overview of recent findings in the synthesis,
evaluation and application of radiolabeled iron oxide nanoparticles as dual-modality SPECT/MRI and PET/MRI imaging
probes.
