Title:Recent Progress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines
Volume: 13
Issue: 4
Author(s): Aiping Huang and Chen Ma
Affiliation:
Keywords:
5-HT3 Receptor agonists, anticancer agents, anti-HIV agents, antimalarial agents, PARP-1 inhibitors,
pyrroloquinoxalines, synthetic methodologies
Abstract: Pyrroloquinoxalines have proved to be a very attractive scaffold for medicinal chemist in the recent past. These
compounds were extensively studied as bioactive compounds and many of them are known to be biologically and
medicinally useful molecules, such as anti-HIV agents, antimalarial agents, antagonist agents, anticancer agents, and
PARP-1 inhibitors. Additionally, pyrroloquinoxalines are also important intermediates for the construction of 5-HT3
receptor agonists. In this review the developments in biological activities and synthetic methodologies of
pyrroloquinoxalines are discussed.