Title:Metal Containing Chloroquinolines: Beyond Hit and Miss Antimalarial Efficacy to Solid Science
Volume: 13
Issue: 4
Author(s): Margaret A.L. Blackie
Affiliation:
Keywords:
Bioinorganic, Chloroquine, Malaria, Metal complex, Plasmodium, Quinoline, falciparum, in vitro
Abstract: Research into metal complexes of known antimalarial drugs have been known for 30 years. Initial exploration
into this field was fairly slow and largely limited to the synthesis of the complexes and reporting of antiplasmodial
efficacy. In the last five years this approach has shifted substantially. Increasingly papers dealing with the mechanism of
action, the speciation of the complexes, and other aspects of the interaction of these complexes in the biological system
are appearing. This shift in focus indicates that the application of bioinorganic and bioorganometallic chemistry are
beginning to mature into well established fields of research. This paper tracks the development of this field from the
humble beginnings to the development of a substantial body of research.