Title:Drug-Glycosidation and Drug Development
Volume: 13
Issue: 4
Author(s): Vijay K. Kapoor and Amanpreet Kaur
Affiliation:
Keywords:
Drug glycosidation, colon targeting, colon targeting through drug glycosides, drug glycosides with varied activities,
synthetic methods, enzymes, syndrome, in vivo
Abstract: Ideally a drug should be administered in a form that it exerts its pharmacological action at the target site using
the lowest concentration possible and without undesirable effects. Drug targeting is the approach which is followed for the
purpose. Among different approaches preparation of synthetic glycosides of target drug and administering them orally is
one of the most recent approaches. The drug glycoside on reaching colonic region releases the active drug through
enzymatic action. This approach has been detailed with different successful examples. Synthetic drug-glycosides, besides
being used as drug targeting agents, have been shown to exhibit varied biological activities such as antineoplastic,
antidiabetic, antiinfllamatory etc., which have been reviewed. Synthetic approaches to O-, C-, N-, S glycosides have been
discussed.