Abstract
Antimicrobial peptides are among the most ancient effectors of host defense. Intersecting lines of research demonstrate that life forms as diverse as plants, insects, and vertebrates employ antimicrobial peptides to kill or neutralize a wide variety of microbial species. Defensins, of which there are three structural sub-families, constitute a major category of host defense peptides in vertebrates. Presented here is a brief history of the emergence of the defensin field with an emphasis on the role of these peptides in mammalian innate immunity.
Keywords: Defensins, host defense, antimicrobial, peptides
Current Pharmaceutical Design
Title: A Pocket Guide to Explorations of the Defensin Field
Volume: 13 Issue: 30
Author(s): Michael E. Selsted
Affiliation:
Keywords: Defensins, host defense, antimicrobial, peptides
Abstract: Antimicrobial peptides are among the most ancient effectors of host defense. Intersecting lines of research demonstrate that life forms as diverse as plants, insects, and vertebrates employ antimicrobial peptides to kill or neutralize a wide variety of microbial species. Defensins, of which there are three structural sub-families, constitute a major category of host defense peptides in vertebrates. Presented here is a brief history of the emergence of the defensin field with an emphasis on the role of these peptides in mammalian innate immunity.
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Cite this article as:
Selsted E. Michael, A Pocket Guide to Explorations of the Defensin Field, Current Pharmaceutical Design 2007; 13 (30) . https://dx.doi.org/10.2174/138161207782110363
DOI https://dx.doi.org/10.2174/138161207782110363 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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