Title:The Association of Collagenase with Human Diseases and its Therapeutic Potential in Overcoming them
Volume: 2
Issue: 1
Author(s): Simran Preet Kaur and Wamik Azmi
Affiliation:
Keywords:
Chronic total occlusions, Clostridium histolyticum, collagen, debridement, Duputyren’s contracture, epidermolysis
bullosa, gelatinase-B, Liver cirrhosis, matrix metalloproteinases, metastasis, microbial collagenase, Peyronie’s disease, proteolysis, rheumatoid arthritis, Scleroderma, therapeutic enzymes
Abstract: Collagen is one of the extremely hard to degrade structural matrix proteins. Collagenases are the enzymes
which bring about the degradation of collagen into small peptides. The contribution of collagenases in several human
diseases includes hyper production of collagenase while some diseases are originated due to inadequate amounts of
collagenase in the body. The management of these diseases includes understanding of collagenase involvement and then
developing the therapeutics for the treatment. This review focuses on the studies of different human diseases related to
collagenases and discusses the strategies adapted to conquer them.
