Title:New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation
Volume: 12
Issue: 1
Author(s): Anne Vincent, Benoit Lattuca, Nolwenn Merlet, Catherine Sportouch-Dukhan and Stephanie Barrere-Lemaire
Affiliation:
Keywords:
Inflammation, myocardial injury, ischemia-reperfusion
Abstract: Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led
to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most
settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable
to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to
give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted
for cardioprotective therapeutic developments.
