Title:Update on the Principles and Novel Local and Systemic Therapies for the Treatment of Non-Infectious Uveitis
Volume: 12
Issue: 1
Author(s): Roberto Gallego-Pinazo, Rosa Dolz-Marco, Sebastian Martinez-Castillo, J. Fernando Arevalo and Manuel Diaz-Llopis
Affiliation:
Keywords:
Anti-relapse treatment, biological therapies, immunosupressive treatment, intravitreal methotrexate, intravitreous
corticosteroid deposits, non-infectious uveitis, therapeutic stages, anti-inflammatory, Immunosuppressive Drugs, chronic anti-relapse treatment
Abstract: Ocular inflammatory disorders constitute a sight-threatening group of diseases that might be managed
according to their severity. Their treatment guidelines experience constant changes with new agents that improve the
results obtained with former drugs. Nowadays we can make use of a five step protocol in which topical, periocular and
systemic corticosteroids remain as the main therapy for non-infectious uveitis. In addition, immunosuppresive drugs can
be added in order to enhance the anti-inflammatory effects and to play the role of corticosteroid-sparing agents. These can
be organized in four other steps: cyclosporine and methotrexate in a second one; azathioprine, mycophenolate and
tacrolimus in a third step; biological anti-TNF drugs in fourth position; and a last one with cyclophosphamide and
chlorambucil. In the present review we go through the main characteristics and complications of all these treatments and
make a rational of this five-step treatment protocol for non-infectious posterior uveitis.
