Title:Immunotherapy in Allergies: An Update
Volume: 12
Issue: 1
Author(s): Zamir Calamita and Simone Bernardino Potthast
Affiliation:
Keywords:
Allergy, asthma, immunotherapy, inflammation, rhinitis, T cells, review, sublingual immunotherapy, TNF receptor-related-protein, Langerhans cells
Abstract: The allergen specific immunotherapy is the administration, in IgE-mediated allergic patients, of a specific
allergen in a gradually increased number to provide protection against allergic symptoms and inflammatory reaction. The
current immunotherapeutic approaches occur by modulating the release of inflammatory mediators involved in allergic
reaction and consequently the inhibition of allergic inflammatory process. Since 1997 several World Associations of
Allergy, Asthma and Immunology, have reviewed this issue, seeking to establish standards for its use. Also many
publications about the immunotherapy’s efficacy, as well as, several guidelines on the use of immunotherapy in the
treatment of allergic are available. This article will focus on the most current evidence about the immunotherapy in
allergies regarding its mechanism of action, effectiveness and practical considerations.
