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Abstract
Physiological changes occurring perinatally and in the first month of life can affect the answer to a pharmacological treatment and the individual response to a drug in terms of efficacy and toxicity is highly variable in the neonatal population. Among potential causes for such variability, differences in drug metabolism may have a great impact.
This article aims to review qualitative and quantitative differences in drug metabolizing enzymes in neonates, since both phase I and phase II metabolic pathways are immature at birth and subject to maturational changes in the first period of extrauterine life.
Moreover, clinical implications will be discussed.
Keywords: Newborns, drugs, enzymes, Drug Metabolizing Enzymes, Perinatal, Neonatal Period, toxicity, phase II, CYP2C, CYP3A5, Sulfation
Current Drug Metabolism
Title:Drug Metabolizing Enzymes in the Perinatal and Neonatal Period: Differences in the Expression and Activity
Volume: 14 Issue: 2
Author(s): Laura Cuzzolin
Affiliation:
Keywords: Newborns, drugs, enzymes, Drug Metabolizing Enzymes, Perinatal, Neonatal Period, toxicity, phase II, CYP2C, CYP3A5, Sulfation
Abstract: Physiological changes occurring perinatally and in the first month of life can affect the answer to a pharmacological treatment and the individual response to a drug in terms of efficacy and toxicity is highly variable in the neonatal population. Among potential causes for such variability, differences in drug metabolism may have a great impact.
This article aims to review qualitative and quantitative differences in drug metabolizing enzymes in neonates, since both phase I and phase II metabolic pathways are immature at birth and subject to maturational changes in the first period of extrauterine life.
Moreover, clinical implications will be discussed.
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Cite this article as:
Cuzzolin Laura, Drug Metabolizing Enzymes in the Perinatal and Neonatal Period: Differences in the Expression and Activity, Current Drug Metabolism 2013; 14 (2) . https://dx.doi.org/10.2174/1389200211314020003
DOI https://dx.doi.org/10.2174/1389200211314020003 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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