Title:Synthetic Routes to Symmetric Bisbenzimidazoles: A Review
Volume: 9
Issue: 4
Author(s): Leena Khanna, Siva S. Panda and Pankaj Khanna
Affiliation:
Keywords:
Bisbenzimidazole, o-phenylenediamine, linkers, one pot synthesis.
Abstract: Bisbenzimidazoles, have shown various biological activities viz. antineoplastic, anti-tumor, anti-fungal, anti-inflammatory, hypoglycemia
treatment and physiological disorders, besides other pharmacological effects. Structural modifications of the benzimidazole
nucleus are being carried out in several ways in order to anticipate enhanced biological activities. The synthesis of bis-benzimidazoles is
one such attempt, where the two benzimidazole nuclei are united together using a variety of linkers and points of linkages. These structural
permutations and combinations have given a large number of available bisbenzimidazole compounds for pharmacological and biological
research. A number of reviews have been published over the past decade on the compilation of the biological activities of
bisbenzimidazoles. However, we could not locate any report covering the general strategies followed for the synthesis of these
compounds. The present review provides an in depth view of synthetic routes for preparation of symmetric bisbenzimidazoles.
