Title:Functional PLGA NPs for Oral Drug Delivery: Recent Strategies and Developments
Volume: 13
Issue: 1
Author(s): L. Martin-Banderas, M. Duran-Lobato, I. Munoz-Rubio, J. Alvarez-Fuentes, M. Fernandez-Arevalo and M. A. Holgado
Affiliation:
Keywords:
Biodistribution, cellular uptake, mucoadhesion, NPs, oral bioavailability, PLGA, targeting
Abstract: This article presents the potential of PLGA nanoparticles for the oral administration of drugs. Different
strategies are used to improve oral absorption of these nanoparticles. These strategies are based on modification of
nanoparticle surface properties. They can be achieved either by coating the nanoparticle surface with stabilizing
hydrophilic bioadhesive polymers or surfactants, or by incorporating biodegradable copolymers containing a hydrophilic
moiety. Some substances such as chitosan, vitamin E, methacrylates, lectins, lecithins, bile salts and RGD molecules are
employed for this purpose. Of especial interest are nanoparticles production methods and, in order to improve oral
bioavailability, the mechanism of each additive.
