Abstract
Intracellular Ca2+ release channels, such as inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), facilitate the release of Ca2+ from intracellular storage organelles in response to extracellular and intracellular stimuli. Consequently, these large, tetrameric proteins play a central role in Ca2+ signalling and Ca2+ homeostasis in virtually all cells. Recent data suggests that intracellular Ca2+ release channels may also have an important pathophysiological function in certain disease states, including cardiac arrhythmias and heart failure. As a result, there has been much interest in the identification and characterization of novel, selective regulators of these channels. In this article, we review the wide array of pharmacological agents that interact directly with intracellular Ca2+ release channels and describe the mechanisms underlying their ability to modify channel function.
Keywords: Ryanodine Receptors, Caffeine, dantrolene, JTV519, PKA hyperphosphorylation, Ruthenium Red
Current Pharmaceutical Design
Title: Pharmacological Regulators of Intracellular Calcium Release Channels
Volume: 13 Issue: 24
Author(s): Duncan J. West and Alan J. Williams
Affiliation:
Keywords: Ryanodine Receptors, Caffeine, dantrolene, JTV519, PKA hyperphosphorylation, Ruthenium Red
Abstract: Intracellular Ca2+ release channels, such as inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), facilitate the release of Ca2+ from intracellular storage organelles in response to extracellular and intracellular stimuli. Consequently, these large, tetrameric proteins play a central role in Ca2+ signalling and Ca2+ homeostasis in virtually all cells. Recent data suggests that intracellular Ca2+ release channels may also have an important pathophysiological function in certain disease states, including cardiac arrhythmias and heart failure. As a result, there has been much interest in the identification and characterization of novel, selective regulators of these channels. In this article, we review the wide array of pharmacological agents that interact directly with intracellular Ca2+ release channels and describe the mechanisms underlying their ability to modify channel function.
Export Options
About this article
Cite this article as:
Duncan J. West and Alan J. Williams , Pharmacological Regulators of Intracellular Calcium Release Channels, Current Pharmaceutical Design 2007; 13 (24) . https://dx.doi.org/10.2174/138161207781368620
DOI https://dx.doi.org/10.2174/138161207781368620 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
Blood-based biomarkers in large-scale screening for neurodegenerative diseases
Disease biomarkers are necessary tools that can be employ in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, prediction, to monitor of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal fluid ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine
Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
![Wayfinder Image](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Evidence for Extensive Non-Endocytotic Translocation of Peptide Nucleic Acids Across Mammalian Plasma Membranes
Current Drug Delivery Structure-Activity Relationships of Histamine H2 Receptor Ligands+
Mini-Reviews in Medicinal Chemistry Beyond Antibody-Mediated Rejection: Hyperacute Lung Rejection as a Paradigm for Dysregulated Inflammation
Current Drug Targets - Cardiovascular & Hematological Disorders Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry Fluoride Effects: The Two Faces of Janus
Current Medicinal Chemistry Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation
Current Drug Targets Species Differences in Hepatocyte-Directed Gene Transfer: Implications for Clinical Translation
Current Gene Therapy Recent Progress in the Development of Quinoline Derivatives for the Exploitation of Anti-Cancer Agents
Anti-Cancer Agents in Medicinal Chemistry Cinnamic Acid Derivatives as Anticancer Agents-A Review
Current Medicinal Chemistry Mesenchymal Stem Cells: New Approaches for the Treatment of Neurological Diseases
Current Stem Cell Research & Therapy Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications
Current Medicinal Chemistry Differentiation-Inducing Therapy for Solid Tumors
Current Pharmaceutical Design Potential Application of Induced Pluripotent Stem Cells in Cell Replacement Therapy for Parkinsons Disease
CNS & Neurological Disorders - Drug Targets Diverse Pharmacological Potential of Pyridazine Analogs against Various Diseases
Medicinal Chemistry Pharmacological Therapies for Pediatric and Neonatal ALI/ARDS: An Evidence-Based Review
Current Drug Targets Neurodevelopmental Delay and Intellectual Disability in Pediatric Heart Transplant
Current Psychiatry Reviews Gender Related Issues in the Management of Heart Failure
Current Pharmaceutical Design Coarctation of the Aorta - An Evolution of Therapeutic Options
Current Cardiology Reviews Inhibitors of HDACs - Effective Drugs Against Cancer?
Current Cancer Drug Targets Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer
Current Molecular Medicine