Title:The Animal Models of Dementia and Alzheimer’s Disease for Pre-Clinical Testing and Clinical Translation
Volume: 9
Issue: 9
Author(s): Akshay Anand, Avijit Banik, Keshav Thakur and Colin L. Masters
Affiliation:
Keywords:
Dementia, memory disorder, spatial memory, preclinical, Alzheimer’s disease, mammalian brains, amnesic agents, hippocampus, sensory neurons activation, hyperphosphorylated Tau.
Abstract: Dementia is a clinical syndrome with abnormal degree of memory loss and impaired ability to recall events
from the past often characterized by Alzheimer’s disease. The various strategies to treat dementia need validation of novel
compounds in suitable animal models for testing their safety and efficacy. These may include novel anti-amnesic drugs
derived from synthetic chemistry or those derived from traditional herbal sources. Multiple approaches have been adopted
to create reliable animal models ranging from rodents to non-human primates, where the animals are exposed to a predetermined
injury or causing genetic ablation across specific regions of brain suspected to affect learning functions. In this
review various animal models for Alzheimer’s disease and treatment strategies in development of anti dementia drugs are
discussed and an attempt has been made to provide a comprehensive report of the latest developments in the field.
