Title:Statins and Portal Hypertension: A New Pharmacological Challenge
Volume: 10
Issue: 6
Author(s): Gonzalo Ramirez, Jimmy Briceno and Armando Rojas
Affiliation:
Keywords:
Liver cirrhosis, statins, portal hypertension, hepatic stellate cell, intrahepatic vascular resistance, vascular
endothelium
Abstract: Portal hypertension is a hemodynamic abnormality that involves a high risk of disability as well as a reduced
life expectancy in patients with cirrhosis. Progress in the knowledge of pathophysiology of portal hypertension has opened
a new perspective for different pharmacological approaches. In this context, the pleiotropic actions of statins on endothelial
cell function have emerged as new options to reduce portal pressure levels by targeting multiple molecular pathways
involved in hepatic vascular homeostasis. We highlight how statins may target some molecular pathways involved in the
pathophysiology of portal hypertension and how these drugs may correct impaired hepatic vascular tone.
