Abstract
The success of detecting cancer at early stages relies greatly on the sensitivity and specificity of in vivo molecular imaging. Optical imaging with near infrared (NIR) luminescent molecular nanoprobes currently attracts much attention because of many advantages of this imaging modality. It provides real time imaging with relatively inexpensive cost, produces images with high sensitivity and spatial resolution, and avoids exposure to ionizing irradiation. Raman spectroscopy/microscopy imaging with surface enhanced Raman scattering (SERS) nanoparticles allows scientists to detect biological events in living cells or organisms in real time and with high sensitivity. The photoacoustic imaging has emerged as a hybrid of optical and ultrasound imaging for sensitive and quantitative tumor detection. Given the recent advances in nanoscience and biomedicine, receptor-targeted NIR nanoprobes promise to improve the cancer early detection with relatively high sensitivity and specificity. We summarize various targeted NIR nanoprobes and their potential applications in cancer targeting and in vivo imaging and discuss the potential of multimodality imaging of NIR nanoprobes. With ongoing efforts to enhance their targeting ability and endow more functions, NIR nanoprobes hold great promise for clinical translation.
Keywords: Near infrared, receptor, nanoparticles, optical fluorescence, cancer, early detection, raman imaging, photoacoustic imaging
Current Medicinal Chemistry
Title:Near Infrared Receptor-Targeted Nanoprobes for Early Diagnosis of Cancers
Volume: 19 Issue: 28
Author(s): K. Cheng and Z. Cheng
Affiliation:
Keywords: Near infrared, receptor, nanoparticles, optical fluorescence, cancer, early detection, raman imaging, photoacoustic imaging
Abstract: The success of detecting cancer at early stages relies greatly on the sensitivity and specificity of in vivo molecular imaging. Optical imaging with near infrared (NIR) luminescent molecular nanoprobes currently attracts much attention because of many advantages of this imaging modality. It provides real time imaging with relatively inexpensive cost, produces images with high sensitivity and spatial resolution, and avoids exposure to ionizing irradiation. Raman spectroscopy/microscopy imaging with surface enhanced Raman scattering (SERS) nanoparticles allows scientists to detect biological events in living cells or organisms in real time and with high sensitivity. The photoacoustic imaging has emerged as a hybrid of optical and ultrasound imaging for sensitive and quantitative tumor detection. Given the recent advances in nanoscience and biomedicine, receptor-targeted NIR nanoprobes promise to improve the cancer early detection with relatively high sensitivity and specificity. We summarize various targeted NIR nanoprobes and their potential applications in cancer targeting and in vivo imaging and discuss the potential of multimodality imaging of NIR nanoprobes. With ongoing efforts to enhance their targeting ability and endow more functions, NIR nanoprobes hold great promise for clinical translation.
Export Options
About this article
Cite this article as:
Cheng K. and Cheng Z., Near Infrared Receptor-Targeted Nanoprobes for Early Diagnosis of Cancers, Current Medicinal Chemistry 2012; 19 (28) . https://dx.doi.org/10.2174/092986712803341458
DOI https://dx.doi.org/10.2174/092986712803341458 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Patent Selections:
Recent Patents on CNS Drug Discovery (Discontinued) Oxidative Phosphorylation as a Target to Arrest Malignant Neoplasias
Current Medicinal Chemistry Key miRNAs in Modulating Aging and Longevity: A Focus on Signaling Pathways and Cellular Targets
Current Molecular Pharmacology A Unique Intracellular, Extracellular and Transmembrane Circulation of Potassium Ions in the Auditory Inner Ear as an Anticarcinogenic Principle? Part 1
Inflammation & Allergy - Drug Targets (Discontinued) Multidisciplinary Cancer Therapy with Telomerase-Specific Oncolytic Adenovirus
Current Cancer Therapy Reviews Multifunctional Nanoparticles, Nanocages and Degradable Polymers as a Potential Novel Generation of Non-Invasive Molecular and Cellular Imaging Systems
Recent Patents on Nanotechnology A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity
Current Drug Targets Synthesis and In Vitro Evaluation of Novel 1,2,3,4-Tetrahydroisoquinoline Derivatives as Potent Antiglioma Agents
Anti-Cancer Agents in Medicinal Chemistry Effectivity of Long Antigen Exposition Dendritic Cell Therapy (LANEXDC<sup>®</sup>) in the Palliative Treatment of Pancreatic Cancer
Current Medicinal Chemistry Novel Homeodomain Transcription Factor Nkx2.2 in the Brain Tumor Development
Current Cancer Drug Targets Introduction: MMPs, ADAMs/ADAMTSs Research Products to Achieve Big Dream
Anti-Cancer Agents in Medicinal Chemistry Preparation of Doughnut-like Nanocomposite Colloidal Crystal Particles with Enhanced Light Diffraction Using Drying Self-assembly Method
Current Nanoscience Taxotere Chemosensitivity Evaluation in Rat Breast Tumor by Multimodal Imaging: Quantitative Measurement by Fusion of MRI, PET Imaging with MALDI and Histology
Recent Patents on Medical Imaging Identification of Imidazoquinoline Derivatives as Potent Antiglioma Agents
Medicinal Chemistry Inhibition of RET Activated Pathways: Novel Strategies for Therapeutic Intervention in Human Cancers
Current Pharmaceutical Design An Analysis of Structure-function Co-relation between GLI Oncoprotein and HLA Immune-gene Transcriptional Regulation through Molecular Docking
Current Cancer Therapy Reviews Chitosan Derivatives with Antimicrobial, Antitumour and Antioxidant Activities - a Review
Current Pharmaceutical Design Up-regulated Circulating miR-106a by DNA Methylation Promised a Potential Diagnostic and Prognostic Marker for Gastric Cancer
Anti-Cancer Agents in Medicinal Chemistry Gene and Cancer Therapy - Pseudorabies Virus: A Novel Research and Therapeutic Tool?
Current Gene Therapy Exploration of (hetero)aryl Derived Thienylchalcones for Antiviral and Anticancer Activities
Medicinal Chemistry