Title:The Developing Utility of Zebrafish Models for Cognitive Enhancers Research
Volume: 10
Issue: 3
Author(s): Adam Michael Stewart and Allan V. Kalueff
Affiliation:
Keywords:
Cognition, cognitive enhancers, drug screening, neurobehavioral disorders, neuroprotective agents, zebrafish
Abstract: Whereas cognitive impairment is a common symptom in multiple brain disorders, predictive and highthroughput
animal models of cognition and behavior are becoming increasingly important in the field of translational
neuroscience research. In particular, reliable models of the cognitive deficits characteristic of numerous neurobehavioral
disorders such as Alzheimer’s disease and schizophrenia have become a significant focus of investigation. While rodents
have traditionally been used to study cognitive phenotypes, zebrafish (Danio rerio) are gaining popularity as an excellent
model to complement current translational neuroscience research. Here we discuss recent advances in pharmacological
and genetic approaches using zebrafish models to study cognitive impairments and to discover novel cognitive enhancers
and neuroprotective mechanisms.
