Title:Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review
Volume: 11
Issue: 1
Author(s): Giuseppe Carlucci, Maura Carlucci and Marcello Locatelli
Affiliation:
Keywords:
NSAIDs, enantiomers, biological fluids, HPLC, prostaglandin biosynthesis, antipyretic drugs, antinflammatory drugs, Etodolac, Fenoprofen, carboxyibuprofen metabolites, non-selective inhibitors, rheumatoid arthritis, osteoarthritis, HPLC assays, pharmacokinetics, chiral drug molecules
Abstract: The analysis of drugs in various biological fluids is an important criterion for the determination of the physiological
performance of a drug. NSAIDs are non-selective inhibitors of prostaglandin biosynthesis and indicated for the
acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. This paper reviews the
recent developments in bioanalysis of these drugs. In particular, sample preparation end, handling procedures, chromatographic
conditions and detection methods are discussed. A summary of published HPLC assays for individual antiinflammatory
drugs is included.
